Serum Ratio of Leptin to Adiponectin in Patients with Chronic Periodontitis and Type 2 Diabetes Mellitus

Xu Jing Ling,1,2 Meng Huan Xin,1 He Lu,1 Wang Xian’E,1 and Zhang Lin3

1Department of Periodontology, School and Hospital of Stomatology, Peking University, Beijing 100191, China
2Department of Stomatology, Peking University Third Hospital, Beijing 100081, China
3Department of Endocrinology, Peking University Third Hospital, Beijing 100191, China

Received 8 September 2013; Accepted 11 December 2013; Published 12 January 2014

Academic Editors: H.-L. Chan, M. L. Kile, and F. Kramer

Copyright © 2014 Xu Jing Ling et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Serum ratio of leptin to adiponectin has been reported to be a useful index of insulin resistance. Since these two adipokines could also be involved in many immunoinflammatory reactions, this ratio might be associated with some inflammatory diseases such as periodontitis. The present study aims to explore the difference in serum ratio of leptin/adiponectin among patients with diabetes and periodontitis, patients with periodontitis only, and healthy people and find out the correlation between this ratio and periodontal parameters. Method. 15 patients with chronic periodontitis and type 2 diabetes, 15 patients with chronic periodontitis only, and 15 healthy controls were selected. Clinical indexes and periodontal parameters were recorded and serum leptin and adiponectin levels were tested by ELISA kits. Result. The ratio of leptin/adiponectin is significantly different among three groups; the T2 DM + CP group has the highest ratio () and the healthy group has the lowest ratio (). What is more, the ratio of leptin/adiponectin has strong positive correlation with periodontal parameters (). Conclusions. Chronic periodontitis could influence the level of adipokines in serum and change the ratio of leptin/adiponectin, and the effect would be enhanced combining with type 2 diabetes.


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